We have looked at nearly every computational approach to drug discovery and believe FAR Biotech’s technology to be the most advanced. FAR can effectively model difficult targets and identify novel compounds that are simply not found by other approaches.
- Pharma Company
o Quantum AI Validation
Early successes against targets in diverse therapeutic areas
We have achieved preclinical validation in several key therapeutic areas including kinases, transcription factors and protein-protein interactions (PPIs) across diverse targets.
- structurally novel leads for Nrf2
- structurally novel leads for Tau aggregation inhibitors
- structurally novel leads for STAT3
- allosteric and active site compounds for BCR-ABL1
- repurposed & novel compounds for liver-stage and blood-stage malariare
- purposed & novel structural compounds for African sleeping sickness
oHigh-impact Target
Our Lead Program: Nrf2
Nrf2 pathway is indicated in Alzheimer’s (7 million cases in US with 500k new cases per year) and Parkinson’s (500,000 cases in US with 90,000 new cases per year) diseases, and plays important role in non-neurological therapeutic areas including lung and kidney disease.
- High-profile target with significant scientific and commercial interest that activates transcriptional program promoting survival and adaptation under cellular stress.
- Well-studied target with dozens of drugs coming up short due to off-target interactions, lack of structural diversity, mechanism-of-action (MOA) concerns (tumorigenesis and liver enzyme elevations) and lack of blood-brain barrier (BBB) penetration, limiting CNS uptake and drug efficacy for neurodegeneration.
- Competition has been modest with only handful of compounds currently in discovery and preclinical phases.
oAragen
Our experimental partner
We work collaboratively with Aragen, a global leader in integrated drug discovery.
25 fully integrated programs with Big Pharma and Biotech
Strong scientific program management capabilities
Clients filed 27 patents in last 6 years
Therapeutic areas: Oncology, pain, inflammation, CVMD, CKD
